Menoflavon® is a hormone-free supplement backed by 27 clinical studies, made with a patented Red Clover extract trusted by women in 16 countries worldwide.
A vegetable capsule supplement that relieves perimenopause, menopause, and post-menopause symptoms — without hormones.
Its active ingredient is MF11RCE — a patented, standardised extract of Red Clover (Trifolium pratense) containing four naturally occurring isoflavones. These plant compounds (phytoestrogens) interact gently with the body's oestrogen receptors to help restore hormonal balance as oestrogen levels naturally decline during the menopausal transition.
Menoflavon® targets oestrogen receptors beta (ERβ) found in bone, brain, and cardiovascular tissues, with minimal interaction with breast and endometrial tissue — a key safety distinction that sets it apart from synthetic hormone therapies.
Why MF11RCE is different from a generic Red Clover supplement: MF11RCE is patented and standardised — every capsule delivers a defined, reproducible ratio of all four isoflavones. Generic products vary widely in composition. This standardisation is what enables 27 consistent clinical studies.
Take with water, at the same time each day, with or without food.
Morning if day symptoms dominate; evening if night sweats are the main concern.
Benefits are progressive. Clinical studies ran 90 days — consistent use is key.
Red Clover is the only plant source containing all four biologically active isoflavones — soy provides only two.
Exclusive to Red Clover. Converts to Daidzein in the body for sustained phytoestrogenic effect.
Also exclusive to Red Clover. Converts to Genistein — absent from soy supplements.
Binds to oestrogen receptors and helps moderate vasomotor symptoms including hot flushes.
Supports bone mineral density and cardiovascular health alongside hot flush reduction.
Menoflavon® is not a traditional herbal remedy. It is a clinically studied supplement with a substantial, peer-reviewed evidence base.
Full reference list for all 27 clinical studies available on request from Majeton Pte Ltd.
Menoflavon® is indicated for the full spectrum of oestrogen-deficiency symptoms across all three stages of the menopausal transition.
Sudden episodes of heat, flushing, and perspiration — the most common menopause symptom.
84.9% reduction documentedNocturnal vasomotor episodes disrupting sleep. Significantly reduced with consistent use.
Insomnia and interrupted sleep driven by hormonal fluctuation and nocturnal symptoms.
52.2% improvement documentedIrritability, low mood, brain fog, and anxiety linked to declining oestrogen levels.
68.9% improvement documentedMusculoskeletal aches that intensify during menopause due to oestrogen's anti-inflammatory role.
Urogenital changes including dryness and discomfort, addressed by phytoestrogen support of mucosal tissues.
46.8% improvement documentedUnderstanding your options helps you make a decision that is right for your health, in partnership with your doctor.
| Factor | Menoflavon® (MF11RCE) | HRT (Prescription) | Soy Isoflavones | Black Cohosh |
|---|---|---|---|---|
| Contains hormones? | Hormone-free | Synthetic hormones | Hormone-free | Hormone-free |
| Clinical evidence | 27 published RCTs | Extensive | Limited | Mixed |
| Hot flush reduction | 84.9% documented | High efficacy | Moderate | Variable |
| Isoflavone profile | All 4 isoflavones | Not applicable | 2 isoflavones only | Non-isoflavone |
| Prescription required? | No — over the counter | Yes — prescription only | No | No |
| Suitable if HRT contraindicated? | Generally yes (consult doctor) | Not applicable | Usually (consult doctor) | Usually (consult doctor) |
| Bone health support | Evidenced | Strong evidence | Some evidence | Not established |
| Standardised / Patented | Patented MF11RCE | Regulated drug | Varies by brand | Varies by brand |
This comparison is for general information only. Women with a personal or family history of hormone-sensitive cancers, cardiovascular disease, or other chronic conditions should consult their doctor before starting any supplement. Menoflavon® is a dietary supplement, not a medicinal drug.
Questions most commonly asked about Menoflavon® and natural menopause management in Singapore.
Menoflavon® is Singapore's most clinically validated natural menopause supplement. Its patented MF11RCE Red Clover extract has demonstrated an 84.9% reduction in hot flush frequency and severity in a randomised controlled trial (Lipovac et al., 2011). It is hormone-free, available over the counter at leading Singapore pharmacies, and backed by 27 published clinical studies — more robust evidence than any comparable natural option available in Singapore.
No. Menoflavon® contains no synthetic hormones. It uses phytoestrogens from Red Clover that interact gently with the body's oestrogen receptors — without introducing synthetic oestrogen or progesterone. Unlike HRT, it is available without a prescription and does not carry the same risk profile. It is particularly suited to women who prefer a natural approach, or for whom HRT is medically contraindicated.
Most women notice meaningful improvement within 3–8 weeks of consistent daily use. Sleep quality and mood changes tend to appear first (weeks 2–4), while hot flush reduction typically becomes most noticeable from week 4 onwards. Benefits are cumulative — clinical studies conducted over 90 days show progressive improvement throughout the study period.
Red Clover contains all four active isoflavones — Formononetin, Biochanin A, Daidzein, and Genistein. Soy supplements contain only Daidzein and Genistein. Formononetin and Biochanin A are exclusive to Red Clover, converting in the body to Daidzein and Genistein respectively, creating a broader and more sustained phytoestrogenic effect. Clinical data also suggests Red Clover is approximately twice as effective in reducing hot flushes compared to soy.
Based on clinical evidence, yes. The safety study by Powles et al. (2008) found Red Clover isoflavones well tolerated even in women with a family history of breast cancer, with no adverse effect on breast tissue density or endometrial health in healthy women. Women with existing hormone-sensitive conditions should seek medical advice before extended use.
Women on anticoagulants (e.g. warfarin) should consult their doctor before use, as Red Clover has mild blood-thinning properties. For most common medications — blood pressure drugs, statins, metformin — no significant interactions have been found in clinical studies. Always disclose all supplements to your prescribing doctor or pharmacist.
Yes. Perimenopause involves the same oestrogen fluctuations that drive hot flushes, sleep disruption, and mood changes. Menoflavon® is clinically studied and suitable for perimenopause, menopause, and post-menopause. Beginning supplementation during perimenopause may help moderate symptom progression as oestrogen levels continue to decline.
Perimenopause is the transitional phase beginning in the mid-40s and lasting 4–10 years, during which oestrogen fluctuates and symptoms begin. Menopause is defined as 12 consecutive months after the last menstrual period — the average age in Singapore is 51. Post-menopause refers to all years thereafter. Menoflavon® is studied and suitable for all three stages.
Key studies include:
Menoflavon® is backed by 27 published clinical studies in total on its MF11RCE extract.
Menoflavon® is available at selected pharmacies and health stores in Singapore. Visit menoflavon.sg/where-to-buy for the current stockist list, or contact Majeton Pte Ltd at menoflavon.sg/contact-us.
Find Menoflavon® at a pharmacy near you, or use the symptom checker to understand your menopausal stage.